O'Brien Amanda, Gaudino-Goering Elizabeth, Shawaryn Marla, Komaroff Eugene, Moore Nancy B, DeLuca John
Kessler Medical Rehabilitation Research and Education Center, 1199 Pleasant Valley Way, West Orange, NJ 07052, USA.
Arch Clin Neuropsychol. 2007 Nov;22(8):933-48. doi: 10.1016/j.acn.2007.07.002. Epub 2007 Sep 11.
To explore the relationship of the Multiple Sclerosis Neuropsychology Questionnaire (MSNQ; [Benedict, R. H. B., Cox, D., Thompson, L. L., Foley, F., Weinstock-Guttman, B., & Munschauer, F. (2004). Reliable screening for neuropsychological impairment in multiple sclerosis. Multiple Sclerosis, 10, 675-678; Benedict, R. H. B., Munschauer, F., Linn, R., Miller, C., Murphy, E., Foley, F., et al. (2003). Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaire. Multiple Sclerosis, 9, 95-101]), a self-report screening measure of neuropsychological functioning in multiple sclerosis (MS), with everyday life functioning, neuropsychological functioning, and mood in MS. Additionally, to investigate the validity, sensitivity, and specificity of the MSNQ to predict cognitive impairment in persons with MS.
Cross-sectional, correlational analyses; analyses of sensitivity and specificity.
Neuropsychology lab-based study with adults from the community including persons with MS (n=48) and healthy adults (n=40).
Subjective and objective measures of everyday life functioning, neuropsychological functioning, and mood; ROC curve of MSNQ-Self report and MSNQ-Informant report, sensitivity and specificity of MSNQ-S and MSNQ-I.
Correlational analyses indicate the MSNQ-S is significantly correlated with mood and self-reports of functioning, but not with objectively measures daily functioning and to only few neuropsychological tests. The MSNQ-I was not significantly correlated to mood, self-report of daily functioning or objectively measured daily functioning, but was significantly correlated with several measures of neuropsychological functioning.
The MSNQ-S was not supported as a sensitive screen for neuropsychological impairment in MS. However, the MSNQ-I was supported as a valid and sensitive screen of cognitive impairment in persons with MS, although further research is needed to determine an optimal cutoff score for this measure.
探讨多发性硬化症神经心理学问卷（MSNQ；[本尼迪克特，R.H.B.，考克斯，D.，汤普森，L.L.，福利，F.，温斯托克 - 古特曼，B.，& 蒙绍尔，F.（2004年）。多发性硬化症神经心理损害的可靠筛查。《多发性硬化症》，10，675 - 678；本尼迪克特，R.H.B.，蒙绍尔，F.，林恩，R.，米勒，C.，墨菲，E.，福利，F.等（2003年）。使用一份15项自评问卷筛查多发性硬化症认知损害。《多发性硬化症》，9，95 - 101]），一种用于多发性硬化症（MS）神经心理功能的自评筛查工具，与MS患者的日常生活功能、神经心理功能和情绪之间的关系。此外，研究MSNQ预测MS患者认知损害的有效性、敏感性和特异性。
横断面相关分析；敏感性和特异性分析。
基于神经心理学实验室的研究，参与者为来自社区的成年人，包括MS患者（n = 48）和健康成年人（n = 40）。
日常生活功能、神经心理功能和情绪的主观及客观测量指标；MSNQ - 自评报告和MSNQ - informant报告的ROC曲线，MSNQ - S和MSNQ - I的敏感性和特异性。
相关分析表明，MSNQ - S与情绪及功能的自评报告显著相关，但与客观测量的日常功能无关，且仅与少数神经心理测试相关。MSNQ - I与情绪、日常功能的自评报告或客观测量的日常功能均无显著相关性，但与多项神经心理功能测量指标显著相关。
MSNQ - S不支持作为MS神经心理损害的敏感筛查工具。然而，MSNQ - I支持作为MS患者认知损害的有效且敏感的筛查工具，尽管需要进一步研究来确定该测量指标的最佳临界值。
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