Vanotti S, Benedict R H B, Acion L, Cáceres F
INEBA - Neurosciences Institute of Buenos Aires, Buenos Aires, Argentina.
Mult Scler. 2009 Feb;15(2):244-50. doi: 10.1177/1352458508097924. Epub 2008 Oct 9.
Considering the lack of screening technology that would permit neurologists to identify patients who may benefit from formal or more comprehensive assessment of neuropsychological status in patients with multiple sclerosis (MS) in Argentina, we felt the need to validate the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ) developed by Benedict, et al.
The objective in this multicenter study was to test the reliability and validity of the MSNQ after translation into Spanish in Argentina. We also compared the MSNQ yield by the patient report with that of the two different informants. The sample included 125 patients with MS and 36 normal controls, 27 patients had two informants available and 23 patients and their informants were examined twice at 1-week intervals (test-retest group). All participants completed the MSNQ, RAO BRB, Beck Depression Inventory-Fast Screen, EDSS, and MS Functional Composite.
We found that an MSNQ-I score of 26 or more resulted in classifications yielding sensitivity of 0.91 and specificity of 0.80, suggesting some utility for this Argentine, informant-report measure.
This Spanish version of the MSNQ is reliable and useful as a screening test for identifying patients at high risk for cognitive impairment in MS.
鉴于在阿根廷缺乏能让神经科医生识别出可能从对多发性硬化症（MS）患者进行正式或更全面神经心理状态评估中获益的患者的筛查技术，我们觉得有必要对Benedict等人开发的多发性硬化症神经心理筛查问卷（MSNQ）进行验证。
这项多中心研究的目的是在阿根廷将MSNQ翻译成西班牙语后测试其可靠性和有效性。我们还比较了患者报告的MSNQ结果与两种不同信息提供者的结果。样本包括125例MS患者和36例正常对照，27例患者有两名信息提供者可供使用，23例患者及其信息提供者在1周间隔内接受了两次检查（重测组）。所有参与者都完成了MSNQ、RAO BRB、贝克抑郁量表快速筛查、扩展残疾状态量表（EDSS）和MS功能综合量表。
我们发现，MSNQ-I得分26分或更高时，分类的敏感性为0.91，特异性为0.80，这表明这种阿根廷的、由信息提供者报告的测量方法有一定作用。
这个西班牙语版MSNQ作为一种筛查测试，对于识别MS中认知障碍高风险患者是可靠且有用的。
