Benedict Ralph H B, Zivadinov Robert
Department of Neurology, School of Medicine, State University of New York, SUNY at Buffalo, Buffalo General Hospital, Neurology, Suite D-6, 100 High Street, 14203, USA.
J Neurol Sci. 2006 Jun 15;245(1-2):67-72. doi: 10.1016/j.jns.2005.05.020. Epub 2006 Apr 19.
Multiple Sclerosis (MS) is associated with MRI signal alteration and neuropsychological (NP) dysfunction. Screening tools have been developed to identify patients at high risk for these neurological complications of MS. One such measure, the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ), has well-established reliability and predictive validity. In this article, we report on the accumulated findings derived from 162 consecutive research participants and MS clinic attendees. Our data show significant correlation between both patient- and informant-report MSNQ and NP impairment. As shown previously, larger, and more significant correlations are found between informant-report MSNQs than with patient-report MSNQs. In addition, we find that the MSNQ predicts follow-up NP testing 51 weeks after baseline with a similar degree of association. Finally, the MSNQ is correlated with MRI measures of whole-brain lesion burden and atrophy, secondary progressive course, and vocational disability. We conclude that the MSNQ is reliable and valid for detecting neuropsychological and neuropsychiatric complications of MS.
多发性硬化症（MS）与磁共振成像（MRI）信号改变及神经心理学（NP）功能障碍相关。已开发出筛查工具来识别MS这些神经并发症的高危患者。其中一项措施，即多发性硬化症神经心理学筛查问卷（MSNQ），具有公认的可靠性和预测效度。在本文中，我们报告了来自162名连续研究参与者和MS门诊患者的累积研究结果。我们的数据显示，患者报告和知情者报告的MSNQ与NP损伤之间均存在显著相关性。如先前所示，与患者报告的MSNQ相比，知情者报告的MSNQ之间存在更大且更显著的相关性。此外，我们发现MSNQ在基线后51周对后续NP测试具有相似程度的关联预测作用。最后，MSNQ与全脑病变负担和萎缩的MRI测量、继发进展病程及职业残疾相关。我们得出结论，MSNQ在检测MS的神经心理学和神经精神并发症方面是可靠且有效的。
