Taveira Aline F, Hyaric Mireille Le, Reis Elaine F C, Araújo Débora P, Ferreira Ana Paula, de Souza Maria Aparecida, Alves Lívia L, Lourenço Maria C S, Vicente Felipe Rodrigues C, de Almeida Mauro V
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG 36036-330, Brazil.
Bioorg Med Chem. 2007 Dec 15;15(24):7789-94. doi: 10.1016/j.bmc.2007.08.045. Epub 2007 Aug 29.
A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5mug/mL. The presence of the carbohydrate slightly affected the antibacterial activity.
合成了一系列N-和C-烷基化氨基醇及其保护的吡喃半乳糖基衍生物，并对其抗结核活性进行了评估。其中五种化合物表现出良好的活性，最低抑菌浓度低于12.5μg/mL。碳水化合物的存在对其抗菌活性有轻微影响。
