氨基醇并色酮类化合物的合成及抗结核活性。
Synthesis and antitubercular activity of amino alcohol fused spirochromone conjugates.
机构信息
Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411 008, India.
出版信息
Bioorg Med Chem Lett. 2013 Mar 1;23(5):1416-9. doi: 10.1016/j.bmcl.2012.12.073. Epub 2013 Jan 5.
PMID:23357635
Abstract
A series of 21 new amino alcohol fused spirochromone conjugates have been synthesized, characterized with analytical data and evaluated their antimycobacterial activity against Mycobacterium tuberculosis (virulent strain H37Rv) in vitro. Some of the compounds exerted significant inhibition, in particular, compound 4f found to be the most potent derivative exhibiting MIC=3.13 μg/mL.
摘要
已经合成了一系列 21 种新的氨基酸醇融合螺色酮缀合物，并用分析数据进行了表征，并评估了它们对结核分枝杆菌（毒力株 H37Rv）的体外抗结核活性。一些化合物表现出显著的抑制作用，特别是化合物 4f，被发现是最有效的衍生物，MIC=3.13μg/mL。
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