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给狗一个基因组。

Give a dog a genome.

作者信息

Mellersh Cathryn

机构信息

Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Newmarket, Suffolk CB8 7UU, UK.

出版信息

Vet J. 2008 Oct;178(1):46-52. doi: 10.1016/j.tvjl.2007.06.029. Epub 2007 Sep 11.

Abstract

In 2004 the dog became only the fifth mammal to have its entire genome fully sequenced. The canine genome was sequenced in the hope that it would help scientists understand the complex evolutionary mechanisms that shape genes and genomes and provide a powerful tool for identifying genetic factors that contribute to human health and disease. It is expected that over the coming years the genome of man's best friend will help in the understanding of the genetic cause of many inherited diseases that humans and dogs have in common. Not only of obvious benefit to humans, these studies will enable the development of DNA diagnostic tests that breeders can use to identify which of their dogs carry mutations that put them at risk of developing particular conditions and thus, over time, eliminate those diseases from the breed.

摘要

2004年,狗成为了第五种全基因组被完全测序的哺乳动物。犬类基因组测序的目的是帮助科学家理解塑造基因和基因组的复杂进化机制,并为识别影响人类健康和疾病的遗传因素提供一个有力工具。预计在未来几年里,人类最好朋友的基因组将有助于理解人类和狗共有的许多遗传性疾病的遗传病因。这些研究不仅对人类有明显益处,还将推动DNA诊断测试的开发,育种者可以利用这些测试来识别哪些狗携带使其有患特定疾病风险的突变,从而随着时间的推移,从犬种中消除这些疾病。

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