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亚利桑那衰老与神经退行性疾病研究以及脑与身体捐赠项目

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program.

作者信息

Beach Thomas G, Adler Charles H, Sue Lucia I, Serrano Geidy, Shill Holly A, Walker Douglas G, Lue LihFen, Roher Alex E, Dugger Brittany N, Maarouf Chera, Birdsill Alex C, Intorcia Anthony, Saxon-Labelle Megan, Pullen Joel, Scroggins Alexander, Filon Jessica, Scott Sarah, Hoffman Brittany, Garcia Angelica, Caviness John N, Hentz Joseph G, Driver-Dunckley Erika, Jacobson Sandra A, Davis Kathryn J, Belden Christine M, Long Kathy E, Malek-Ahmadi Michael, Powell Jessica J, Gale Lisa D, Nicholson Lisa R, Caselli Richard J, Woodruff Bryan K, Rapscak Steven Z, Ahern Geoffrey L, Shi Jiong, Burke Anna D, Reiman Eric M, Sabbagh Marwan N

机构信息

Banner Sun Health Research Institute, Sun City, Arizona, USA.

Mayo Clinic, Scottsdale, Arizona, USA.

出版信息

Neuropathology. 2015 Aug;35(4):354-89. doi: 10.1111/neup.12189. Epub 2015 Jan 26.

DOI:10.1111/neup.12189
PMID:25619230
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4593391/
Abstract

The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain-only donations and currently has banked more than 1600 brains. More than 430 whole-body donations have been received since this service was commenced in 2005. The collective academic output of the BBDP is now described as the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Most BBDP subjects are enrolled as cognitively normal volunteers residing in the retirement communities of metropolitan Phoenix, Arizona. Specific recruitment efforts are also directed at subjects with Alzheimer's disease, Parkinson's disease and cancer. The median age at death is 82. Subjects receive standardized general medical, neurological, neuropsychological and movement disorders assessments during life and more than 90% receive full pathological examinations by medically licensed pathologists after death. The Program has been funded through a combination of internal, federal and state of Arizona grants as well as user fees and pharmaceutical industry collaborations. Subsets of the Program are utilized by the US National Institute on Aging Arizona Alzheimer's Disease Core Center and the US National Institute of Neurological Disorders and Stroke National Brain and Tissue Resource for Parkinson's Disease and Related Disorders. Substantial funding has also been received from the Michael J. Fox Foundation for Parkinson's Research. The Program has made rapid autopsy a priority, with a 3.0-hour median post-mortem interval for the entire collection. The median RNA Integrity Number (RIN) for frozen brain and body tissue is 8.9 and 7.4, respectively. More than 2500 tissue requests have been served and currently about 200 are served annually. These requests have been made by more than 400 investigators located in 32 US states and 15 countries. Tissue from the BBDP has contributed to more than 350 publications and more than 200 grant-funded projects.

摘要

班纳太阳健康研究所的大脑与身体捐赠项目（BBDP）（http://www.brainandbodydonationprogram.org）始于1987年，最初仅接受大脑捐赠，目前已储存了1600多个大脑。自2005年这项服务启动以来，已收到430多例全身体捐赠。BBDP的学术成果现在被称为亚利桑那衰老与神经退行性疾病研究（AZSAND）。大多数BBDP受试者是居住在亚利桑那州凤凰城大都市退休社区的认知正常志愿者。特定的招募工作也针对患有阿尔茨海默病、帕金森病和癌症的受试者。死亡时的中位年龄为82岁。受试者在生前接受标准化的一般医学、神经学、神经心理学和运动障碍评估，超过90%的受试者在死后接受有医学执照的病理学家进行的全面病理检查。该项目通过内部、联邦和亚利桑那州的拨款以及用户费用和制药行业合作等多种方式获得资金。该项目的一些子集被美国国立衰老研究所亚利桑那阿尔茨海默病核心中心以及美国国立神经疾病与中风研究所帕金森病及相关疾病国家大脑与组织资源中心使用。还从迈克尔·J·福克斯帕金森研究基金会获得了大量资金。该项目将快速尸检作为优先事项，整个样本的中位死后间隔时间为3.0小时。冷冻大脑和身体组织的中位RNA完整性数值（RIN）分别为8.9和7.4。已满足了2500多个组织请求，目前每年约满足200个。这些请求来自美国32个州和15个国家的400多名研究人员。BBDP的组织已促成了350多篇出版物和200多个由拨款资助的项目。

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