Barnes P J
National Heart and Lung Institute, University of London, UK.
Trends Biochem Sci. 1991 Oct;16(10):365-9. doi: 10.1016/0968-0004(91)90152-l.
Asthma is a chronic condition of the airways that involves many types of inflammatory cell and the release of many mediators and neurotransmitters that have multiple effects on the various target cells in the airway. There have been important advances in understanding the biochemical events involved in signal transduction in inflammatory cells, in mediator synthesis and release, in contraction and relaxation of airway smooth muscle and in neural mechanisms. This may lead to more effective and specific therapies for this common but complex disease.
哮喘是一种气道慢性疾病，涉及多种类型的炎症细胞以及多种介质和神经递质的释放，这些介质和神经递质对气道中的各种靶细胞具有多种作用。在理解炎症细胞信号转导、介质合成与释放、气道平滑肌收缩与舒张以及神经机制等所涉及的生化事件方面已经取得了重要进展。这可能会为这种常见但复杂的疾病带来更有效和更具特异性的治疗方法。
