Valcheva S, Belcheva A
Department of Pharmacology, Medical University of Varna, Bulgaria.
Agents Actions. 1994 Jun;41 Spec No:C108-10. doi: 10.1007/BF02007789.
The antispasmogenic and spasmolytic effects of the calcium entry blocker verapamil were examined on histamine-induced guinea pig tracheal contraction in vitro in comparison with the beta 2-adrenergic agonist salbutamol. The effects of verapamil were found to be about 1000 times weaker than those of salbutamol. The antispasmogenic IC50 for verapamil was 1.99 x 10(-4) M compared to 7.94 x 10(-8) M for salbutamol. The spasmolytic EC50 for verapamil was 3.37 x 10(-5) M and for salbutamol was 1.95 x 10(-8) M. The combined application of verapamil and salbutamol resulted in additive antispasmogenic and spasmolytic effects.
将钙通道阻滞剂维拉帕米的抗痉挛和缓解痉挛作用与β2肾上腺素能激动剂沙丁胺醇进行比较，在体外研究了其对组胺诱导的豚鼠气管收缩的影响。发现维拉帕米的作用比沙丁胺醇弱约1000倍。维拉帕米的抗痉挛IC50为1.99×10（-4）M，而沙丁胺醇为7.94×10（-8）M。维拉帕米的解痉EC50为3.37×10（-5）M，沙丁胺醇为1.95×10（-8）M。维拉帕米和沙丁胺醇联合应用产生了相加的抗痉挛和解痉作用。
