Sondhi A, Talukdar B
Biochemistry Department, Maulana Azad Medical College, N. Delhi.
Indian J Clin Biochem. 2000 Aug;15(1):44-7. doi: 10.1007/BF02873547.
In view of several reports that there is a lack of balance in free radicals in case of bronchial asthma (1) the effect of free radicals on cell membrane was studied by estimating the membrane bound protein Na(+), K(+)-ATPase activity and the intracellular sodium level in patients of bronchial asthma before and after a short course (one week) of oral corticosteroid (prednisolone 0.75-1mg/kg body weight) therapy. Results showed that there is a definite statistically significant rise in free radical level and intracellular sodium level and a significant lowering of Na(+), K(+)-ATPase activity in case of untreated bronchial asthma. After short course of therapy with oral corticosteroids, the free radical level and intracellular sodium level decreased significantly, together with a significant rise of the Na(+), K(+)-ATPase activity. Also, a significant negative correlation (r=-0.74) between the lipid peroxide level and the Na(+),-K(+)-ATPase activity was found in these cases.
鉴于有几份报告指出支气管哮喘患者体内自由基失衡(1)，通过评估口服皮质类固醇(泼尼松龙0.75 - 1mg/kg体重)短疗程(一周)治疗前后支气管哮喘患者的膜结合蛋白钠钾ATP酶活性和细胞内钠水平，研究了自由基对细胞膜的影响。结果显示，未经治疗的支气管哮喘患者自由基水平和细胞内钠水平有统计学意义的显著升高，钠钾ATP酶活性显著降低。口服皮质类固醇短疗程治疗后，自由基水平和细胞内钠水平显著下降，同时钠钾ATP酶活性显著升高。此外，在这些病例中发现脂质过氧化物水平与钠钾ATP酶活性之间存在显著负相关(r = -0.74)。
