Qu Guirong, Zhang Zhiguang, Guo Haiming, Geng Mingwei, Xia Ran
College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, PR China.
Molecules. 2007 Mar 19;12(3):543-51. doi: 10.3390/12030543.
A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.
开发了一种简单、快速且具有区域选择性的方法来合成N-(甲氧羰基甲基)-和N-(正丙氧羰基甲基)核碱基。以N,N-二甲基甲酰胺为溶剂,碳酸钾为碱,在微波辐射下8分钟内以中等产率得到了所有所需产物。