微波促进的N-（烷氧羰基甲基）核碱基的简便高效制备——肽核酸的构建模块
Microwave-promoted facile and efficient preparation of N-(alkoxycarbonylmethyl) nucleobases--building blocks for peptide nucleic acids.
作者信息
Qu Guirong, Zhang Zhiguang, Guo Haiming, Geng Mingwei, Xia Ran
机构信息
College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, PR China.
出版信息
Molecules. 2007 Mar 19;12(3):543-51. doi: 10.3390/12030543.
Abstract
A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.
摘要
开发了一种简单、快速且具有区域选择性的方法来合成N-(甲氧羰基甲基)-和N-(正丙氧羰基甲基)核碱基。以N,N-二甲基甲酰胺为溶剂，碳酸钾为碱，在微波辐射下8分钟内以中等产率得到了所有所需产物。
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