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受阻酚与杂环相连的合成、氧化还原性质和抗菌活性。

Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles.

机构信息

Department of organic chemistry and petroleum chemistry, Gubkin Russian State University of Oil and Gas, Leninsky av. 65, 119991 Moscow, Russia.

出版信息

Molecules. 2020 May 20;25(10):2370. doi: 10.3390/molecules25102370.

Abstract

A series of benzotriazole, cyclic amides and pyrimidine derivatives, containing 2,6-di--butyl-phenol fragments, were synthesized. The redox properties of obtained compounds were studied using the cyclic voltammetry on a platinum electrode in acetonitrile. The oxidation potentials of all substances were comparable to those of BHT. The obtained compounds were tested for their antibacterial activity, and -(2-(3,5-di--butyl-4-hydroxyphenyl)-2-oxoethyl)isatin (32 μg/mL) exerted good activity against

摘要

合成了一系列含有 2,6-二叔丁基苯酚片段的苯并三唑、环状酰胺和嘧啶衍生物。在乙腈中使用铂电极的循环伏安法研究了所得化合物的氧化还原性质。所有物质的氧化电位都与 BHT 的氧化电位相当。对所得化合物进行了抗菌活性测试,发现(2-(3,5-二叔丁基-4-羟基苯基)-2-氧代乙基)靛红(32μg/mL)对具有良好的活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7b0/7287627/344bff58992f/molecules-25-02370-g001.jpg

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