洛伊卡特-瓦拉赫反应在合成四氢-1,4-苯并二氮杂䓬-5-酮文库中的新应用。
Novel application of Leuckart-Wallach reaction for synthesis of tetrahydro-1,4-benzodiazepin-5-ones library.
作者信息
Lee Sung-Chan, Park Seung Bum
机构信息
Department of Chemistry, Seoul National University, Seoul 151-747, Korea.
出版信息
Chem Commun (Camb). 2007 Sep 28(36):3714-6. doi: 10.1039/b709768a. Epub 2007 Aug 8.
DOI:10.1039/b709768a
PMID:17851604
Abstract
A novel and efficient strategy has been developed to synthesize privileged tetrahydro-1,4-benzodiazepines with excellent yields and purities; this synthetic pathway was established by the revitalization of the Leuckart-Wallach (LW) reaction via solid-phase synthesis.
摘要
已开发出一种新颖且高效的策略来合成具有优异产率和纯度的特殊四氢-1,4-苯二氮䓬类化合物；该合成途径是通过固相合成使洛伊卡特-瓦拉赫（LW）反应复苏而建立的。
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