Rudenko L G, Ramirez A, Barro M, Gushchina M I, Armanda R E, Ermachenko T A, Romanova Iu R, Grigor'eva E P, Aleksandrova G I, Lonskaia N I
Vopr Virusol. 1991 Nov-Dec;36(6):472-4.
The reactogenicity and immunizing activity of vaccine influenza virus A (H1N1) and B strains used as mono- and bi-preparations in children of 3 to 14 years was studied. No increased reactogenicity after the use of bivaccine was observed in the children. Febrile reactions as well as 9 other clinical symptoms which could indicate the reactogenicity of the vaccines were identical for mono- and bivaccine and corresponded to the requirements of the technical documents for the vaccine. The optimal conditions for the evaluation of the immunogenicity of the B component by HI test were developed, and the necessity of using additionally the enzyme immunoassay for this purpose is substantiated. The above method demonstrated that the immunogenicity of the live influenza type A and B vaccine was high in children. No significant inhibition of immunological parameters was observed when the two viruses were combined in the bivaccine.
研究了甲型（H1N1）流感病毒和乙型流感病毒株作为单价和双价制剂在3至14岁儿童中的反应原性和免疫活性。在儿童中未观察到使用双价疫苗后反应原性增加。单价疫苗和双价疫苗的发热反应以及其他9种可能表明疫苗反应原性的临床症状相同，并且符合疫苗技术文件的要求。制定了通过血凝抑制试验评估B组分免疫原性的最佳条件，并证实了为此目的额外使用酶免疫测定的必要性。上述方法表明，甲型和乙型流感活疫苗在儿童中的免疫原性很高。当两种病毒在双价疫苗中组合时，未观察到免疫参数的显著抑制。
