Grigor'eva E P, Rekstin A R, Rudenko L G, Ramirez A, Barro M, Lisovskaia K V, Klimov A I, Aleksandrova G I
Vopr Virusol. 1994 Jan-Feb;39(1):26-9.
Production lots of a live influenza vaccine made of strains A/47/T (N1H1), A/47/6/2 (H3N2), and B/60/32 were used for vaccination of 3663 children aged from 5 to 14 years inoculated twice with monovaccines, a trivaccine made of the above strains, or placebo. Both mono- and polyvaccine were practically areactogenic. An average per cent of subjects with a significant rise in antibody titres to the respective three antigens was 60%. The efficacy of the vaccination was 31.0-42.8% for monopreparations and 36.3% for the trivaccine. The studies showed the possibility and expedience of using for children the live influenza vaccine in the form of a polyvalent preparation including current influenza type A and B viruses.
用A/47/T（N1H1）、A/47/6/2（H3N2）和B/60/32毒株制成的一批流感活疫苗，用于对3663名5至14岁儿童进行接种，这些儿童分别接种单价疫苗、由上述毒株制成的三价疫苗或安慰剂，接种两次。单价疫苗和多价疫苗实际上都无反应原性。对三种相应抗原抗体滴度显著升高的受试者平均百分比为60%。单价制剂的疫苗效力为31.0 - 42.8%，三价疫苗为36.3%。研究表明，以包含当前甲型和乙型流感病毒的多价制剂形式为儿童使用流感活疫苗具有可能性和便利性。
