Montes Jacqueline, Cheng Bin, Diamond Beverly, Doorish Carolyn, Mitsumoto Hiroshi, Gordon Paul H
Department of Neurology, College of Physicians and Surgeons, The Eleanor and Lou Gehrig MDA/ALS Research Center, Columbia University, New York, NY 10032, USA.
Amyotroph Lateral Scler. 2007 Oct;8(5):292-5. doi: 10.1080/17482960701435931.
There are few functionally meaningful clinical measures used to guide management of patients with ALS. Falls are common, can be debilitating, and result in increased health care costs. We assessed the performance and ability to predict falls of the Timed Up and Go (TUG) test, which quantifies walking ability, in a prospective longitudinal study. Thirty-one patients underwent six monthly TUG, ALSFRS-R, forced vital capacity, muscle testing (MMT) and quality of life assessments. Linear and generalized linear mixed effects models assessed the associations among variables and ability to predict falls. The increase in TUG time was linear over six months, and TUG time was negatively associated with ALSFRS-R (p< or =0.001) and MMT scores (p< or =0.001). The TUG test was the only variable that was associated with the chance of falling (p = 0.024); patients with TUG times of 14 s had a 10% chance of falling during the study. In conclusion, TUG performance declined linearly in this longitudinal study, was correlated with standard outcome measures, and predicted falls. The TUG test can guide management of patients with ALS; a time of 14 s can be used to prompt the recommendation for mobility aids to prevent falls.
用于指导肌萎缩侧索硬化症（ALS）患者管理的具有功能意义的临床指标很少。跌倒很常见，可能使人虚弱，并导致医疗保健成本增加。在一项前瞻性纵向研究中，我们评估了计时起立行走（TUG）测试预测跌倒的性能和能力，该测试可量化行走能力。31名患者每六个月接受一次TUG测试、ALS功能评定量表修订版（ALSFRS-R）、用力肺活量、肌肉测试（MMT）和生活质量评估。线性和广义线性混合效应模型评估了变量之间的关联以及预测跌倒的能力。TUG时间在六个月内呈线性增加，且TUG时间与ALSFRS-R（p≤0.001）和MMT评分（p≤0.001）呈负相关。TUG测试是唯一与跌倒可能性相关的变量（p = 0.024）；在研究期间，TUG时间为14秒的患者有10%的跌倒几率。总之，在这项纵向研究中，TUG表现呈线性下降，与标准结局指标相关，并能预测跌倒。TUG测试可指导ALS患者的管理；14秒的时间可用于促使推荐使用移动辅助设备以预防跌倒。
