Ballantyne Angela O, Spilkin Amy M, Trauner Doris A
Department of Neuroscience, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Child Neuropsychol. 2007 Nov;13(6):494-509. doi: 10.1080/09297040601114878.
The goal of this study was to examine structured language skills in children with perinatal strokes. Participants were 28 school-age children with early focal brain lesions (17 with left hemisphere [LH] damage, 11 with right hemisphere [RH] damage), and 57 controls. A standardized test of language (Clinical Evaluation of Language Fundamentals-Revised) was administered. Receptive, Expressive, and Total Language scores, as well as subtest scores, were analyzed. Control participants scored within the normal range, whereas the LH and RH groups scored significantly more poorly than did controls. There were no differences between the LH and RH groups on any of the language scores, and all scores were below the 14th percentile. Within the lesion group as a whole, scores were not related to lesion laterality, site, or severity. Results also were not accounted for by socioeconomic status or IQ. However, children who experienced seizures demonstrated significantly poorer performance than did children who did not experience seizures. Damage to either the LH or RH early in development adversely affects later language abilities, particularly on tasks with structured and complex linguistic demands. Although lesion side has little effect, the presence or absence of seizures is a major contributor to language outcome.
本研究的目的是检查围产期中风患儿的结构化语言技能。研究对象为28名患有早期局灶性脑损伤的学龄儿童（17名左半球[LH]受损，11名右半球[RH]受损）以及57名对照组儿童。采用标准化语言测试（语言基本能力临床评估修订版）进行评估。分析了接受性、表达性和总语言得分以及各子测试得分。对照组参与者得分在正常范围内，而LH组和RH组的得分明显低于对照组。LH组和RH组在任何语言得分上均无差异，且所有得分均低于第14百分位。在整个损伤组中，得分与损伤的侧别、部位或严重程度无关。结果也不受社会经济地位或智商的影响。然而，经历过癫痫发作的儿童表现明显比未经历过癫痫发作的儿童差。发育早期LH或RH受损会对后期语言能力产生不利影响，尤其是在具有结构化和复杂语言要求的任务上。尽管损伤侧的影响较小，但癫痫发作的有无是语言结果的主要影响因素。
