Savilahti E, Tainio V M, Salmenperä L, Arjomaa P, Kallio M, Perheentupa J, Siimes M A
Children's Hospital, University of Helsinki, Finland.
Acta Paediatr Scand. 1991 Dec;80(12):1207-13. doi: 10.1111/j.1651-2227.1991.tb11810.x.
During a nutritional study of 198 infants, seven became allergic to cow's milk. The seven infants showed acute cutaneous manifestations during cow's milk challenge tests in hospital and six had increased levels of IgE cow's milk-specific antibodies. Neither in the development of the levels of immunoglobulins G, A and M, nor in that of the cow's milk-specific antibodies of these isotypes did these seven patients differ from the remaining infants. Beta-lactoglobulin content and levels of cow's milk-, and beta-lactoglobulin-specific antibodies and of immunoglobulins A, G and M were measured in samples of colostrum and milk from the mothers of the seven infants with cow's milk allergy and from a comparison group (non-atopic mothers of non-atopic infants). The milk of the mothers whose infants became allergic to cow's milk contained less IgA through the lactation: 95% confidence intervals of the groups did not overlap. The difference was most marked in the colostrum. All other measurements were similar in the two groups. This suggests that an infant is more likely to develop cow's milk allergy if the mother's colostrum had a low total IgA content.
在一项针对198名婴儿的营养研究中，有7名婴儿对牛奶过敏。这7名婴儿在医院进行牛奶激发试验时出现了急性皮肤表现，其中6名婴儿的牛奶特异性IgE抗体水平升高。这7名患者在免疫球蛋白G、A和M水平的发展以及这些同种型的牛奶特异性抗体水平的发展方面与其余婴儿没有差异。对7名牛奶过敏婴儿的母亲以及对照组（非特应性婴儿的非特应性母亲）的初乳和乳汁样本中的β-乳球蛋白含量、牛奶特异性和β-乳球蛋白特异性抗体以及免疫球蛋白A、G和M水平进行了测量。婴儿对牛奶过敏的母亲的乳汁在整个哺乳期含有的IgA较少：两组的95%置信区间没有重叠。这种差异在初乳中最为明显。两组的所有其他测量结果相似。这表明，如果母亲的初乳中总IgA含量较低，婴儿更有可能发生牛奶过敏。
