Leippold Thomas, Preusser Stefan, Engeler Daniel, Inhelder Fabienne, Schmid Hans-Peter
Department of Urology, Kantonsspital, St. Gallen, Switzerland.
Scand J Urol Nephrol. 2008;42(1):18-23. doi: 10.1080/00365590701520503. Epub 2007 Aug 2.
The procedure of prostate biopsy is often performed but has not been standardized. Therefore, a survey of all urologists in Switzerland was carried out to investigate indications, patient preparation and technique with regard to transrectal prostate biopsy.
A questionnaire was mailed to all 178 urologists working in Switzerland, either as self-employed urologists (SEUs) or as employed urologists at a hospital (EUHs), i.e. a teaching centre.
The questionnaire was returned by 133 urologists (75%). Eighty-seven of the respondents (65%) are SEUs and 46 (35%) work as EUHs. If digital rectal examination (DRE) raises suspicion of cancer, 129 urologists perform a biopsy. A serum prostate-specific antigen (PSA) level of 4 ng/ml is used as a cut-off value by 84% of respondents (SEUs 83%, EUHs 87%). A fluoroquinolone antibiotic is prescribed by 126 of the respondents. Fifty-nine percent of respondents (SEUs 52%, EUHs 72%) are offering periprostatic injection of a local anaesthetic drug. At the initial biopsy, 24% of respondents (SEUs 30%, EUHs 13%) obtain six cores, 45% (SEUs 37%, EUHs 61%) 8-10 and 17% (SEUs 18%, EUHs 15%) > or =12. The subsequent procedure performed after two negative biopsy sessions varies considerably.
This survey provides an insight into the practice pattern of urologists in Switzerland concerning prostate biopsy. For almost all urologists, a positive DRE is an indication for prostate biopsy. The majority use a serum PSA level of 4 ng/ml as a cut-off value. A fluoroquinolone is the antibiotic of choice. Periprostatic nerve block is the commonest form of anaesthesia. Most urologists take 8-10 cores per biopsy.
前列腺活检操作虽常进行,但尚未标准化。因此,对瑞士所有泌尿科医生开展了一项调查,以研究经直肠前列腺活检的适应症、患者准备情况及技术。
向在瑞士工作的所有178名泌尿科医生邮寄了一份问卷,这些医生要么是个体开业泌尿科医生(SEU),要么是在医院(即教学中心)工作的受雇泌尿科医生(EUH)。
133名泌尿科医生(75%)回复了问卷。其中87名受访者(65%)是个体开业泌尿科医生,46名(35%)是受雇泌尿科医生。如果直肠指检(DRE)怀疑有癌症,129名泌尿科医生会进行活检。84%的受访者(个体开业泌尿科医生为83%,受雇泌尿科医生为87%)将血清前列腺特异性抗原(PSA)水平4 ng/ml用作临界值。126名受访者会开具氟喹诺酮类抗生素。59%的受访者(个体开业泌尿科医生为52%,受雇泌尿科医生为72%)会进行前列腺周围局部麻醉药注射。在初次活检时,24%的受访者(个体开业泌尿科医生为30%,受雇泌尿科医生为13%)取6条组织芯,45%(个体开业泌尿科医生为37%,受雇泌尿科医生为61%)取8 - 10条,17%(个体开业泌尿科医生为18%,受雇泌尿科医生为15%)取≥12条。两次活检结果为阴性后的后续操作差异很大。
这项调查深入了解了瑞士泌尿科医生在前列腺活检方面的实践模式。对于几乎所有泌尿科医生来说,DRE阳性是前列腺活检的适应症。大多数人将血清PSA水平4 ng/ml用作临界值。氟喹诺酮类是首选抗生素。前列腺周围神经阻滞是最常见的麻醉方式。大多数泌尿科医生每次活检取8 - 10条组织芯。