Olbrich Hans M, Valerius Gabriele, Rüsch Nicolas, Buchert Martin, Thiel Thorsten, Hennig Jürgen, Ebert Dieter, Van Elst Ludger Tebartz
Section for Experimental NeuroPsychiatry, Department of Psychiatry, Albert-Ludwigs-University, Freiburg, Germany.
World J Biol Psychiatry. 2008;9(1):59-63. doi: 10.1080/15622970701227811.
Glutamatergic dysfunction has been implicated in the pathophysiology of schizophrenia. In this study we performed absolute-quantification short-echo magnetic resonance spectroscopy (MRS) in nine patients with first episode schizophrenia and 32 group-matched control subjects to test the hypothesis of glutamatergic dysfunction at disease onset. Regions of interest were the left dorsolateral prefrontal cortex and the left hippocampus. In the patient group absolute concentrations of glutamate were significantly higher in the prefrontal cortex and near-significantly higher in the hippocampus. The glutamate signals significantly correlated with rating scores for schizophreniform symptoms. Absolute-quantification [1H]MRS can reveal glutamatergic abnormalities which might play an important role in the pathogenesis and course of schizophrenia.
谷氨酸能功能障碍与精神分裂症的病理生理学有关。在本研究中，我们对9例首发精神分裂症患者和32名年龄匹配的对照受试者进行了绝对定量短回波磁共振波谱（MRS）检查，以验证疾病发作时谷氨酸能功能障碍的假说。感兴趣的区域是左侧背外侧前额叶皮质和左侧海马体。在患者组中，前额叶皮质中谷氨酸的绝对浓度显著升高，海马体中的浓度接近显著升高。谷氨酸信号与精神分裂症样症状的评分显著相关。绝对定量[1H]MRS可以揭示谷氨酸能异常，这可能在精神分裂症的发病机制和病程中起重要作用。
