Yoshida A, Kodama Y, Hatanaka S, Takasaki T, Kuriwaki K, Yoshida H
First Department of Pathology, Kagoshima University, Faculty of Medicine, Japan.
Acta Pathol Jpn. 1991 Dec;41(12):927-32. doi: 10.1111/j.1440-1827.1991.tb01641.x.
A case of apocrine adenocarcinoma arising in the bilateral axillae is reported. The patient was an 88-year-old Japanese male who complained of a mass lesion and pus-like discharge in the right axilla. Another mass was also noticed in the left axilla. No other neoplastic lesion was found in other sites of the body. The histologic appearances of the bilateral axillary tumors were almost identical. Both were adenocarcinoma with varying degrees of differentiation, composed of glands and nests of atypical epithelial cells with abundant eosinophilic cytoplasm. Some neoplastic cells exhibited cytoplasmic projections on their apical surface. Foci of in situ carcinoma were observed within the neoplastic tissue in the bilateral axillae. The neoplastic cells were immunohistochemically positive for epithelial membrane antigen (EMA) and gross cystic disease fluid protein (GCDFP-15), but negative for carcinoembryonic antigen (CEA). On the basis of their histologic and immunohistochemical features and distinctive location, the tumors were diagnosed as apocrine adenocarcinoma.
报告了一例发生于双侧腋窝的大汗腺腺癌。患者为一名88岁的日本男性，主诉右腋窝有一肿块及脓性分泌物。左腋窝也发现了另一肿块。身体其他部位未发现其他肿瘤性病变。双侧腋窝肿瘤的组织学表现几乎相同。两者均为不同程度分化的腺癌，由具有丰富嗜酸性细胞质的腺体和非典型上皮细胞巢组成。一些肿瘤细胞在其顶端表面有细胞质突起。在双侧腋窝的肿瘤组织内观察到原位癌灶。肿瘤细胞上皮膜抗原（EMA）和乳腺囊肿病液体蛋白（GCDFP-15）免疫组化呈阳性，但癌胚抗原（CEA）呈阴性。根据其组织学和免疫组化特征以及独特的位置，这些肿瘤被诊断为大汗腺腺癌。
