Nowak M, Pathan A, Fatteh S, Fatteh S, Lopez J
Department of Pathology, Western Reserve Care System, Youngstown, OH 44501, USA.
Am J Dermatopathol. 1998 Aug;20(4):422-4. doi: 10.1097/00000372-199808000-00019.
A 39-year-old man presented with a 2-cm, mildly tender mass in the right breast of many years' duration. Microscopic examination showed a syringocystadenoma papilliferum. Because of its location in the breast, we studied the lesion for immunohistochemical markers for apocrine differentiation. Gross cystic disease fluid protein-15 (GCDFP-15) staining yielded negative results in the cystic luminal epithelial cells, whereas GCDFP-15 and lysozyme staining yielded strongly positive results in the epithelial cells of adjacent tubular apocrine glands. Focal strong lysozyme positivity was seen in the cystic luminal epithelial cells. These findings do not support apocrine differentiation in this case, despite its location in the breast, an organ rich in specialized apocrine (lactiferous) glands. To our knowledge, this represents the first reported case of syringocystadenoma papilliferum of the male breast. We present the clinical and pathologic features of this unusual case and a review of the literature.
一名39岁男性患者，右侧乳房出现一个2厘米大小、轻度压痛的肿块，已持续多年。显微镜检查显示为乳头状汗腺囊腺瘤。由于其位于乳房，我们研究了该病变的顶泌汗腺分化免疫组化标志物。大体囊肿性疾病液蛋白-15（GCDFP-15）染色在囊腔内上皮细胞中呈阴性结果，而GCDFP-15和溶菌酶染色在相邻管状顶泌汗腺的上皮细胞中呈强阳性结果。在囊腔内上皮细胞中可见局灶性强溶菌酶阳性。尽管该病变位于富含特殊顶泌汗腺（乳腺）的乳房，但这些发现不支持该病例中的顶泌汗腺分化。据我们所知，这是男性乳房乳头状汗腺囊腺瘤的首例报道病例。我们展示了这一罕见病例的临床和病理特征并对文献进行了综述。
