Gajović Olgica, Canović Predrag, Mijailović Zeljko, Lazić Zorica
Klinicko-bolnicki centar Kragujevac, Odeljenje za infektivne bolesti.
Med Pregl. 2007 Jan-Feb;60(1-2):12-8. doi: 10.2298/mpns0702012g.
Due to current increase in the rate of nosocomial infections, our objective was to examine the frequency, risk factors, clinical presentation and etiology of nosocomial infections in patients with central nervous system infections. 2246 patients with central nervous system infections, treated in the intensive care units of the Institute of Infectious and Tropical Diseases, Clinical Center of Serbia in Belgrade and at the Department of Infectious Diseases of the Clinical Hospital Center Kragujevac, were included in this retrospective and prospective study. Clinical manifestations of nosocomial infections were registered in 180 (12.7%) patients. Direct risk factors for nosocomial infections were: venous lines, urinary catheter, length of stay over 20 days, inhibitors of gastric secretion, consciousness disorders and coma, endotracheal intubation, tracheotomy and controlled ventilation for 5 days or more. The most frequent clinical presentations of nosocomial infections were: tract urinary infections, bacteriemia/sepsis and nosocomial pneumonia. Significantly higher frequency of death outcomes was registered in patients with nosocomial infections.
由于目前医院感染率上升，我们的目标是研究中枢神经系统感染患者医院感染的发生率、危险因素、临床表现及病因。本回顾性和前瞻性研究纳入了2246例在塞尔维亚贝尔格莱德临床中心传染病与热带病研究所重症监护病房以及克拉古耶瓦茨临床医院中心传染病科接受治疗的中枢神经系统感染患者。180例（12.7%）患者记录到医院感染的临床表现。医院感染的直接危险因素为：静脉置管、导尿管、住院时间超过20天、胃分泌抑制剂、意识障碍和昏迷、气管插管、气管切开以及5天或更长时间的控制通气。医院感染最常见的临床表现为：泌尿系统感染、菌血症/败血症和医院获得性肺炎。医院感染患者的死亡结局发生率显著更高。
