（18）氟代脱氧葡萄糖正电子发射断层显像/X线计算机体层成像（F-DG PET/CT）在结直肠癌复发和转移检测中的应用
(18)F-DG PET/CT in detection of recurrence and metastasis of colorectal cancer.
作者信息
Chen Long-Bang, Tong Jin-Long, Song Hai-Zhu, Zhu Hong, Wang Yu-Cai
机构信息
Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China.
出版信息
World J Gastroenterol. 2007 Oct 7;13(37):5025-9. doi: 10.3748/wjg.v13.i37.5025.
Abstract
AIM
To evaluate the value of (18)F-DG PET/CT in detecting recurrence and/or metastasis of colorectal cancer (CRC).
METHODS
Combined visual analysis with semiquantitative analysis, the (18)F-DG PET/CT whole-body imaging results and the corresponding clinical data of 68 postoperative CRC patients including 48 male and 20 female with average age of 58.1 were analyzed retrospectively.
RESULTS
Recurrence and/or metastasis were confirmed in 56 patients in the clinical follow-up after the PET/CT imaging. The sensitivity of PET/CT diagnosis of CRC recurrence and/or metastasis was 94.6%, and the specificity was 83.3%. The positive predictive value (PPV) was 96.4% and the negative predictive value (NPV) was 76.9%. PET/CT imaging detected one or more occult malignant lesions in 8 cases where abdominal/pelvic CT and/or ultrasonography showed negative findings, and also detected more lesions than CT or ultrasonography did in 30.4% (17/56) cases. Recurrence and/or metastasis was detected in 91.7% (22/24) cases with elevated serum CEA levels by (18)F-DG PET/CT imaging.
CONCLUSION
(18)F-DG PET/CT could detect the recurrence and/or metastasis of CRC with high sensitivity and specificity.
摘要
目的
评估¹⁸F - DG PET/CT在检测结直肠癌（CRC）复发和/或转移中的价值。
方法
采用视觉分析与半定量分析相结合的方法，回顾性分析68例CRC术后患者的¹⁸F - DG PET/CT全身成像结果及相应临床资料，其中男性48例，女性20例，平均年龄58.1岁。
结果
PET/CT成像后临床随访中56例患者确诊复发和/或转移。PET/CT诊断CRC复发和/或转移的敏感性为94.6%，特异性为83.3%。阳性预测值（PPV）为96.4%，阴性预测值（NPV）为76.9%。PET/CT成像在8例腹部/盆腔CT和/或超声检查结果为阴性的病例中检测到一个或多个隐匿性恶性病变，并且在30.4%（17/56）的病例中检测到的病变比CT或超声检查更多。¹⁸F - DG PET/CT成像在血清CEA水平升高的91.7%（22/24）的病例中检测到复发和/或转移。
结论
¹⁸F - DG PET/CT能够以高敏感性和特异性检测CRC的复发和/或转移。
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