Chen Mei-Huei, Chen Pau-Chung, Jeng Suh-Fang, Hsieh Chia-Jung, Su Feng-Chiao, Liao Hua-Fang, Su Yi-Ning, Lin Shio-Jean, Hsieh Wu-Shiun
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
J Paediatr Child Health. 2008 Apr;44(4):166-9. doi: 10.1111/j.1440-1754.2007.01215.x. Epub 2007 Sep 14.
The living style, health-care system and socio-economic environments have changed substantially in Taiwan over past 20 years. This study was aimed to estimate the current perinatal cytomegalovirus (CMV) seroprevalence in northern Taiwan.
In a Taiwan Birth Panel Study, 483 pairs of mothers and neonates were prospectively recruited from one tertiary medical center, one local hospital, and two obstetric clinics located in northern Taiwan from April 2004 through January 2005. Sera of their paired maternal and cord blood were tested by an enzyme-linked immunosorbent assay method for CMV IgG and IgM antibodies. Additional data were collected for health measures and epidemiological characteristics through trained interviewers utilising structured questionnaires.
Among 483 mothers studied, 93% were Taiwanese, 6.4% were immigrants from the south-eastern Asia and Mainland China, and 0.6% was aborigines. The seropositive rate of CMV IgG and IgM among the mothers was 91.1% and 3.5%, respectively. The immigrant mothers and the mothers younger than 20 years of age had a higher IgM seroprevalence (P < 0.05). Furthermore, 90.8% of the offspring had CMV IgG seropositivity and yet none of the neonates were CMV IgM positive.
The seroprevalence of CMV among childbearing women is high in northern Taiwan. The immigrant mothers and the teenage mothers appear to have higher seropositivity of CMV IgM.
在过去20年里，台湾的生活方式、医疗保健系统和社会经济环境发生了巨大变化。本研究旨在评估台湾北部目前围产期巨细胞病毒（CMV）的血清流行率。
在一项台湾出生队列研究中，从2004年4月至2005年1月，前瞻性招募了483对母婴，这些母婴来自台湾北部的一家三级医疗中心、一家当地医院和两家产科诊所。采用酶联免疫吸附测定法检测其配对的母血和脐血中的CMV IgG和IgM抗体。通过经过培训的访员使用结构化问卷收集有关健康指标和流行病学特征的其他数据。
在研究的483名母亲中，93%为台湾人，6.4%为东南亚和中国大陆移民，0.6%为原住民。母亲中CMV IgG和IgM的血清阳性率分别为91.1%和3.5%。移民母亲和年龄小于20岁的母亲IgM血清流行率较高（P<0.05）。此外，90.8%的后代CMV IgG呈血清阳性，但没有新生儿CMV IgM呈阳性。
台湾北部育龄妇女中CMV的血清流行率较高。移民母亲和青少年母亲的CMV IgM血清阳性率似乎较高。
