Gleicher Norbert
Center for Human Reproduction, New York, NY 10021, USA.
Autoimmun Rev. 2007 Sep;6(8):572-6. doi: 10.1016/j.autrev.2007.04.002. Epub 2007 May 21.
Medical conditions with known etiology and typical peripartal/postpartal disease exacerbations are now, without exception, considered autoimmune in etiology. Postpartum psychiatric conditions, and especially postpartum depression, currently, however, are still not understood in their etiology. This paper suggests that the typical postpartum flare pattern, and other clinical characteristics, point towards an autoimmune etiology for (postpartum) depression. The high prevalence of (postpartum) depression led to its designation as a major public health problem. A better understanding of etiology and pathophysiology would greatly advance the, currently still inaccurate, diagnosis of the condition, and improve approaches towards prevention and treatment.
目前，病因已知且在围产期/产后疾病有典型加重情况的医学病症无一例外都被认为病因是自身免疫性的。然而，产后精神疾病，尤其是产后抑郁症，目前其病因仍未明确。本文认为，典型的产后发作模式及其他临床特征表明（产后）抑郁症的病因是自身免疫性的。（产后）抑郁症的高患病率使其被认定为一个重大的公共卫生问题。更好地理解其病因和病理生理学将极大地推动目前仍不准确的该病症诊断，并改进预防和治疗方法。
