Orfanos C E, Mahrle G
Dermatologica. 1975;151(4):199-215.
The system glycocalyz - membrane bound enzymes - cAMP may be regarded as a regulatory mechanism for the control of epidermal growth. The glycocalyz of the epithelial cell membrane is obviously a receptor and accumulator for agents stimulating adenyl cyclase and other membrane-bound enzymes of energy utilisation; cAMP, on the other hand, serves as an intracellular 'mediator' between proliferative stimuli and the DNA of the keratinocytes. Numerous cytological, cytochemical, and enzymatic biochemical studies indicate that this mechanism is profoundly disturbed in psoriasis, particularly at the membrane-bound stage.
糖萼 - 膜结合酶 - 环磷酸腺苷系统可被视为控制表皮生长的一种调节机制。上皮细胞膜的糖萼显然是刺激腺苷酸环化酶及其他能量利用膜结合酶的物质的受体和蓄积部位；另一方面，环磷酸腺苷在增殖刺激与角质形成细胞的DNA之间充当细胞内“介质”。大量细胞学、细胞化学及酶促生物化学研究表明，该机制在银屑病中受到严重干扰，尤其是在膜结合阶段。
