Rüstow B, Metz D, Kunze D, Meffert H
Arch Dermatol Res. 1981;270(4):441-4. doi: 10.1007/BF00403788.
Psoriasis is marked by loss of glycoalyx. Glycocalyx is composed of glycoproteins and glycolipids such as cerebrosides. It was shown that the incorporation of 14C-linoleic acid in cerebrosides of normal and psoriatic human skin is different. In psoriatic epidermis and corium the turnover of this fatty acid is significantly elevated. It is suggested that in psoriasis the epidermal cell is not able to build up a regular carbohydrate sequences of lipids because the false carbohydrate chain activates the degradation of glycolipids and in compensating for the increased degradation raises the synthesis rate of glycolipids.
银屑病的特征是糖萼缺失。糖萼由糖蛋白和糖脂（如脑苷脂）组成。研究表明，正常人和银屑病患者皮肤脑苷脂中14C-亚油酸的掺入情况不同。在银屑病的表皮和真皮中，这种脂肪酸的周转显著加快。有人提出，在银屑病中，表皮细胞无法构建正常的脂质碳水化合物序列，因为错误的碳水化合物链激活了糖脂的降解，为补偿增加的降解，提高了糖脂的合成速率。
