Khosrowbeygi Ali, Zarghami Nosratollah
Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran.
Prostaglandins Leukot Essent Fatty Acids. 2007 Aug;77(2):117-21. doi: 10.1016/j.plefa.2007.08.003. Epub 2007 Sep 12.
The lipid composition of the sperm membrane has a significant effect on the functional characteristics of spermatozoa.
In the present study, fatty acid composition of spermatozoa and seminal plasma levels of free 15-F(2t)-Isoprostane and catalase were assayed in men with normozoospermia, asthenozoospermia, asthenoteratozoospermia, and oligoasthenoteratozoospermia.
In spermatozoa from asthenozoospermic men only oleic acid levels showed a significant difference from normozoospermic men. In spermatozoa from asthenoteratozoospermic and oligoasthenoteratozoospermic samples all of the tested fatty acids were significantly higher than those from normozoospermic samples. Seminal plasma levels of catalase were significantly lower in all patients while levels of free 15-F(2t)-Isoprostane were significantly higher in all patients compared with normozoospermic men.
Spermatozoa from pathological samples may have higher levels of polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), than spermatozoa from normozoospermic men. Therefore, damage induced by lipid peroxidation would be higher in spermatozoa from pathological samples than those from normozoospermic men.
精子膜的脂质组成对精子的功能特性有显著影响。
在本研究中，对患有正常精子症、弱精子症、弱畸精子症和少弱畸精子症的男性进行了精子脂肪酸组成以及精液中游离15-F(2t)-异前列腺素和过氧化氢酶水平的检测。
在弱精子症男性的精子中，仅油酸水平与正常精子症男性存在显著差异。在弱畸精子症和少弱畸精子症样本的精子中，所有检测的脂肪酸均显著高于正常精子症样本。与正常精子症男性相比，所有患者精液中的过氧化氢酶水平均显著降低，而游离15-F(2t)-异前列腺素水平均显著升高。
病理样本中的精子可能比正常精子症男性的精子含有更高水平的多不饱和脂肪酸，尤其是二十二碳六烯酸（DHA）。因此，病理样本中的精子因脂质过氧化引起的损伤会高于正常精子症男性的精子。
