Sanusi I D, Tio F O, Manno J E
Forensic Sci. 1975 Dec;6(3):165-74. doi: 10.1016/0300-9432(75)90007-2.
It is known among forensic and pediatric pathologists that the demonstration of pancreatic inclusions is considered to have diagnostic significance in cases of boric acid poisoning. Fisher was the first to suggest a causal relationship between the inclusions and boric acid toxicity. Valdes-Dapena and Arey paid particular attention to the pancreatic inclusions in reviewing the literature of cases of boric acid poisoning. They found the inclusions in 6 of the 55 autopsies. This paper describes the finding of pancreatic inclusions in a fatal case of gastro-enteritis not associated with boric acid intoxication. The nature of the inclusion bodies was studied by light and electron microscopy. Ultrastructurally, the cytoplasmic inclusions represent a non-specific autophagic cell degenerative process. Toxicological examination of postmortem blood and viscera showed no evidence of boric acid toxicity. The desirability of toxicological analysis in cases of boric acid poisoning and the restricted value of pancreatic inclusions as a diagnostic tool are emphasised.
法医病理学家和儿科病理学家都知道，在硼酸中毒病例中，胰腺内含物的显示被认为具有诊断意义。费舍尔是第一个提出内含物与硼酸毒性之间存在因果关系的人。巴尔德斯 - 达佩纳和阿里在回顾硼酸中毒病例文献时特别关注了胰腺内含物。他们在55例尸检中的6例中发现了内含物。本文描述了在一例与硼酸中毒无关的致命胃肠炎病例中发现胰腺内含物的情况。通过光学显微镜和电子显微镜研究了包涵体的性质。在超微结构上，细胞质内含物代表一种非特异性的自噬性细胞退行性过程。死后血液和内脏的毒理学检查未显示硼酸中毒的证据。强调了硼酸中毒病例中毒理学分析的必要性以及胰腺内含物作为诊断工具的有限价值。
