Egfjord M, Jansen J A, Flachs H, Schou J S
Medical Department P, Rigshospitalet, Denmark.
Hum Toxicol. 1988 Mar;7(2):175-8. doi: 10.1177/096032718800700212.
A mixture containing 3 g of boric acid and 300 mg of cinchocaine chloride prescribed due to painful dental protrusion was accidentally ingested by a 12-month-old girl. She developed violent vomiting and coughing. Irritability, tremor, seizures and a delirious reaction. She was treated with diazepam, intubated, sedated and ventilated. Her diuresis was stimulated with furosemide and fluid. Within the first 24 h she was treated with haemodialysis twice on femoral catheters. Her renal function was unaffected. In two days she fully recovered. The maximum measured levels of boric acid and cinchocaine chloride approximately 6 h after ingestion were 26 micrograms/ml and 71 ng/ml respectively. The plasma half-life of boric acid was 7.0 h and decreased to 3.6 and 4.4 h during the two haemodialyses. The total body clearance of boric acid increased correspondingly from 21 ml/min to 41 and 34 ml/min. The in vitro clearance of boric acid of the dialyser was later determined to be 18 ml/min. It is concluded that haemodialysis is valuable in the treatment of boric acid intoxication because it increases the elimination of the drug even in patients without any sign of renal toxicity.
一名12个月大的女孩因牙齿突出疼痛而误服了一种含有3克硼酸和300毫克氯化辛可卡因的混合物。她出现了剧烈呕吐和咳嗽。还出现了易怒、震颤、癫痫发作和谵妄反应。她接受了地西泮治疗，进行了插管、镇静和通气。用速尿和液体刺激她的利尿。在最初的24小时内，她通过股静脉导管进行了两次血液透析。她的肾功能未受影响。两天后她完全康复。摄入后约6小时测得的硼酸和氯化辛可卡因的最高水平分别为26微克/毫升和71纳克/毫升。硼酸的血浆半衰期为7.0小时，在两次血液透析期间分别降至3.6小时和4.4小时。硼酸的全身清除率相应地从21毫升/分钟增加到41毫升/分钟和34毫升/分钟。后来测定透析器对硼酸的体外清除率为18毫升/分钟。得出的结论是，血液透析在治疗硼酸中毒方面很有价值，因为即使在没有任何肾毒性迹象的患者中，它也能增加药物的清除。
