Tsukamoto S, Kanegae T, Saito M, Nagoya T, Shimamura M, Tainaka H, Kawaguchi M
Department of Legal Medicine, Nihon University School of Medicine.
Arukoru Kenkyuto Yakubutsu Ison. 1991 Dec;26(6):500-10.
Blood and urine samples were analyzed for ethanol, acetaldehyde, acetate and acetone during experimental hangover in 6 healthy male volunteers (A, B, C, D, E, F). They drank freely for some 4 hr. In flushers (A, F) at 9 hr after ingestion (ethanol: 92 g, 1.2 g/kg and 1.3 g/kg), acetaldehyde levels were low in the blood, but high in the urine (37 microM, 45 microM). Heavy drinkers, non-flushers of B (ethanol: 176 g, 2.5 g/kg), C (157 g, 2.4 g/kg) and E (182 g, 2.9 g/kg) had a slightly high [lactate]/[pyruvate] ratio and 3-hydroxybutyrate in the blood at 11 hr after alcohol ingestion. Blood ethanol levels were dose dependent and blood acetaldehyde in B and C had a slightly high 6.3 microM and 8.0 microM 9 hr later, respectively. B, C and E had a high urine acetone concentration (100 microM over) in hangover. In C, in particular, urine acetate and acetone levels were unusually high. The ratio in blood (urine) among alcohol metabolites at 9 hr after drinking was approximately ethanol 1000 (1000): acetaldehyde 0.2-1.0 (0.1-5.9): acetate 36-163 (22-1554): acetone 1-11 (3-47).
在6名健康男性志愿者（A、B、C、D、E、F）的实验性宿醉期间，对血液和尿液样本进行了乙醇、乙醛、乙酸盐和丙酮的分析。他们自由饮酒约4小时。在饮酒后9小时，对于脸红者（A、F）（乙醇摄入量分别为92克、1.2克/千克和1.3克/千克），血液中的乙醛水平较低，但尿液中的乙醛水平较高（37微摩尔/升、45微摩尔/升）。重度饮酒者，即B（乙醇摄入量：176克、2.5克/千克）、C（157克、2.4克/千克）和E（182克、2.9克/千克）这些非脸红者，在饮酒后11小时血液中的[乳酸]/[丙酮酸]比值和3-羟基丁酸水平略有升高。血液乙醇水平呈剂量依赖性，9小时后B和C血液中的乙醛水平分别略高，为6.3微摩尔/升和8.0微摩尔/升。B、C和E在宿醉时尿液中的丙酮浓度较高（超过100微摩尔/升）。特别是C，尿液中的乙酸盐和丙酮水平异常高。饮酒后9小时血液（尿液）中酒精代谢物的比例约为乙醇1000（1000）：乙醛0.2 - 1.0（0.1 - 5.9）：乙酸盐36 - 163（22 - 1554）：丙酮1 - 11（3 - 47）。
