[氧甲环酸对急性磷酰甲胆碱中毒猫大脑皮质微循环及神经冲动活动的影响]

[Effects of oxymethacil on microcirculation and neuronal impulse activity in the cat cerebral cortex in acute fosfakol poisoning].

作者信息

Kamenev A L, Samoĭlov M O, Semenov D G, Sofronov G A

出版信息

Biull Eksp Biol Med. 1991 Aug;112(8):115-7.

Abstract

By using the methods of vital microscopy and extracellular registration of the neuronal activity the effect of oxymethacil (OM) on microcirculation and NSA in cat brain cortex was studied after grave poisoning by organophosphate paraoxon. The rapid depression of NSA together with the pronounced disturbances of microcirculation in cortical vessels were showed after intravenous injection of paraoxon (0.8 mg/kg). The prophylactic injection of OM (5 mg/kg) induced protective effect on the studied parameters. This effect was more pronounced when OM injection was combined with the M-cholinolytic amyzyl. The present data show the reasonableness of antioxidants using for the correction of a brain functional condition damaged by organophosphates.

摘要

采用活体显微镜检查和神经元活动细胞外记录的方法，研究了在猫脑皮质严重有机磷对氧磷中毒后，甲氧苯烯（OM）对微循环和非特异性脑电活动（NSA）的影响。静脉注射对氧磷（0.8mg/kg）后，出现了NSA的快速抑制以及皮质血管微循环的明显紊乱。预防性注射OM（5mg/kg）对所研究的参数产生了保护作用。当OM注射与M-胆碱能阻滞剂阿米齐尔联合使用时，这种作用更为明显。目前的数据表明，使用抗氧化剂来纠正受有机磷损害的脑功能状态是合理的。

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