[The participation of intracellular regulatory systems in the reactions of the cat cerebral cortical neurons to fosfakol].

The effects of paraoxon (1.5-4.5 LD50) on the levels of intracellular regulatory components, such as membrane-bound calcium (Ca(b)) and polyphosphoinositides (PPI) were studied along with microcirculation and neuronal bioelectric activity control in the feline cerebral cortex. There was a relation between these parameters, which supports the important role of Ca(b) and PPI in the mechanism of paraoxon's neurotoxic action. Taking into account the findings, it is advisable to use a complex of drugs in organophosphate intoxication, which will correct the mechanisms of intracellular signal transduction.