Samoĭlov M O, Sofronov G A, Kamenev A L, Semenov D G, Tiul'kova E I
Eksp Klin Farmakol. 1994 Jul-Aug;57(4):13-6.
The effects of paraoxon (1.5-4.5 LD50) on the levels of intracellular regulatory components, such as membrane-bound calcium (Ca(b)) and polyphosphoinositides (PPI) were studied along with microcirculation and neuronal bioelectric activity control in the feline cerebral cortex. There was a relation between these parameters, which supports the important role of Ca(b) and PPI in the mechanism of paraoxon's neurotoxic action. Taking into account the findings, it is advisable to use a complex of drugs in organophosphate intoxication, which will correct the mechanisms of intracellular signal transduction.
研究了对氧磷（1.5 - 4.5倍半数致死剂量）对细胞内调节成分水平的影响，如膜结合钙（Ca(b)）和多磷酸肌醇（PPI），同时还研究了猫大脑皮层的微循环和神经生物电活动控制。这些参数之间存在关联，这支持了Ca(b)和PPI在对氧磷神经毒性作用机制中的重要作用。考虑到这些发现，在有机磷中毒时使用一组药物是可取的，这将纠正细胞内信号转导机制。
