Zhang X, Li S, Fan D
Xijing Hospital, Xi'an.
Chin Med Sci J. 1991 Mar;6(1):56-9.
In order to facilitate early diagnosis and improve the treatment of gastric cancer, 12 murine hybridoma cell lines capable of producing monoclonal antibodies (mAb) against gastric cancer were established. These monoclonal antibodies were used in histopathological diagnosis, cytological and serological diagnosis, and radioimmunoimaging (RII). Also, immunoconjugates and immunoliposomes were produced by linking these antibodies with various anticancer agents. In vitro and in vivo studies in mice were carried out to investigate the possible uses of these antibodies in experimental targeting therapy of gastric cancer. This paper presents a review of these studies.
为了促进胃癌的早期诊断并改善其治疗，建立了12株能够产生抗胃癌单克隆抗体（mAb）的小鼠杂交瘤细胞系。这些单克隆抗体被用于组织病理学诊断、细胞学和血清学诊断以及放射免疫显像（RII）。此外，通过将这些抗体与各种抗癌剂连接来制备免疫缀合物和免疫脂质体。在小鼠身上进行了体外和体内研究，以探讨这些抗体在胃癌实验性靶向治疗中的可能用途。本文对这些研究进行了综述。
