Kondo Seiji, Tanimoto Kazuki, Okamura Seiichi
Department of Hematology and Clinical Research Institute, Kyushu Medical Center.
Rinsho Ketsueki. 2007 Aug;48(8):632-6.
A 69-year-old female with rheumatoid arthritis was admitted to our hospital with facial flushing and cervical lymphadenopathy on Jan, 2006. She had been treated with methotrexate (MTX), sulfasalazine (SSA) and prednisolone. The MTX and SSA were discontinued because of appetite loss just before admission. The patient's white blood cell count was 30100/microl with 32.5% of plasma cells, and 25.7% of plasma cells were observed in the bone marrow. Immunoelectrophoresis revealed polyclonal hypergammaglobulinemia on admission. Flow cytometry analysis revealed that the plasma cells in the bone marrow expressed CD38 and CD19 and did not express CD56. The lymphadenopathy and the increase of plasma cells in the peripheral blood and the bone marrow gradually decreased after the cessation of MTX and SSA.
一名69岁的类风湿关节炎女性患者于2006年1月因面部潮红和颈部淋巴结肿大入住我院。她此前一直在接受甲氨蝶呤（MTX）、柳氮磺胺吡啶（SSA）和泼尼松龙治疗。入院前因食欲减退停用了MTX和SSA。患者白细胞计数为30100/微升，浆细胞占32.5%，骨髓中浆细胞占25.7%。入院时免疫电泳显示多克隆高球蛋白血症。流式细胞术分析显示骨髓中的浆细胞表达CD38和CD19，不表达CD56。停用MTX和SSA后，淋巴结肿大以及外周血和骨髓中浆细胞数量逐渐减少。
