Wolf George
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
Nutr Rev. 2007 Aug;65(8 Pt 1):385-8. doi: 10.1301/nr.2007.aug.385-388.
Retinol-binding protein (RBP) is the transport protein that carries retinol in the circulation from the liver to its target tissues. The existence of a cell-surface receptor on the target cells, which mediates the uptake of retinol from RBP, has been known since 1975. Recently, it was identified as an integral transmembrane protein named STRA6 that is inducible by retinoic acid in certain cancer cells. The receptor was found to be highly specific for RBP, with high affinity, and to be localized in all tissues known to require retinol for their function, particularly the pigment epithelium of the eye.
视黄醇结合蛋白（RBP）是一种转运蛋白，它在血液循环中将视黄醇从肝脏输送到其靶组织。自1975年以来，人们就知道靶细胞上存在一种细胞表面受体，该受体介导视黄醇从RBP的摄取。最近，它被鉴定为一种名为STRA6的完整跨膜蛋白，在某些癌细胞中可被视黄酸诱导。该受体被发现对视黄醇结合蛋白具有高度特异性、高亲和力，并且定位于所有已知对视黄醇功能有需求的组织中，尤其是眼睛的色素上皮。
