Firáková S, Proksa B, Sturdíkova M
Department of Biochemical Technology, Institute of Biotechnology and Food Industry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovak Republic.
Pharmazie. 2007 Aug;62(8):563-8.
Enniatins are N-methylated cyclohexadepsipeptides (CHDPs), composed of three units each of N-methylated branched-chain L-amino acid and D-2-hydroxy acid arranged in an alternate fashion. These low-molecular secondary metabolites are produced by Fusarium species, typical mycotoxin producing fungi. Enniatins are known for their ionophoric, phytotoxic and anthelmintic effect, antibiotic activity and recently their potent cytotoxic activity against cancer cell lines was shown. They act also as inhibitors of drug efflux pumps. Biosynthesis, biological activity, and the structural characteristics of these microbial metabolites were summarized in this review.
恩镰孢菌素是N-甲基化的环六肽缩酚酸肽(CHDPs),由三个N-甲基化支链L-氨基酸和D-2-羟基酸单元交替排列组成。这些低分子次生代谢产物由镰刀菌属产生,镰刀菌属是典型的产真菌毒素真菌。恩镰孢菌素以其离子载体、植物毒性和驱虫作用、抗生素活性而闻名,最近还显示出对癌细胞系的强大细胞毒性活性。它们还可作为药物外排泵的抑制剂。本文综述了这些微生物代谢产物的生物合成、生物活性和结构特征。