用于 N-取代的 1,3-二氢苯并咪唑-2-酮的级联偶联/环化过程
Cascade coupling/cyclization process to N-substituted 1,3-dihydrobenzimidazol-2-ones.
作者信息
Zou Benli, Yuan Qiliang, Ma Dawei
机构信息
Department of Chemistry, Fudan University, Shanghai 200433, China.
出版信息
Org Lett. 2007 Oct 11;9(21):4291-4. doi: 10.1021/ol701792j. Epub 2007 Sep 15.
PMID:17867696
Abstract
Assembly of N-substituted 1,3-dihydrobenzimidazol-2-ones is achieved starting from methyl o-haloarylcarbamates via a CuI/amino acid catalyzed coupling with amines and subsequent condensative cyclization. A number of functional groups are tolerated by these reaction conditions, including vinyl, nitro, carboxylate, amide, ester, ketone, and silyl ether groups.
摘要
从邻卤代芳基氨基甲酸甲酯出发，通过碘化亚铜/氨基酸催化的与胺的偶联反应以及随后的缩合环化反应，实现了N-取代的1,3-二氢苯并咪唑-2-酮的组装。这些反应条件能够耐受多种官能团，包括乙烯基、硝基、羧酸盐、酰胺、酯、酮和硅醚基团。
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