Diepgen Thomas L, Agner Tove, Aberer Werner, Berth-Jones John, Cambazard Frédéric, Elsner Peter, McFadden John, Coenraads Pieter Jan
Department of Clinical Social Medicine, Occupational & Environmental Dermatology, University Hospital Heidelberg, Heidelberg 69115, Germany.
Contact Dermatitis. 2007 Oct;57(4):203-10. doi: 10.1111/j.1600-0536.2007.01179.x.
Hand eczema (HE) is one of the most frequent skin diseases and has often a chronically relapsing course with a poor prognosis resulting in a high social and economic impact for the individual and the society. In this article, we highlight the results of an expert workshop on the 'management of severe chronic hand eczema' with the focus on the epidemiology, the burden of severe HE, its classification and diagnostic procedures, and the current status of treatment options according to an evidence-based approach (randomized controlled clinical trials, RCTs). We conclude that despite the abundance of topical and systemic treatment options, disease management in patients with severe chronic HE is frequently inadequate. There is a strong need for RCTs of existing and new treatment options based on clearly diagnosed subtypes of HE and its severity.
手部湿疹（HE）是最常见的皮肤疾病之一，通常病程呈慢性复发性，预后较差，给个人和社会带来巨大的社会和经济影响。在本文中，我们重点介绍了一次关于“重度慢性手部湿疹管理”的专家研讨会的成果，内容聚焦于流行病学、重度手部湿疹的负担、其分类和诊断程序，以及基于循证方法（随机对照临床试验，RCT）的治疗选择现状。我们得出结论，尽管有丰富的局部和全身治疗选择，但重度慢性手部湿疹患者的疾病管理往往并不充分。基于明确诊断的手部湿疹亚型及其严重程度，对现有和新的治疗选择进行随机对照试验的需求十分迫切。
