Wu J J, Weinstein G D, Kricorian G J, Kormeili T, McCullough J L
Department of Dermatology, University of California, Irvine, Irvine, CA 92697-2400, USA.
Clin Exp Dermatol. 2007 Nov;32(6):693-5. doi: 10.1111/j.1365-2230.2007.02513.x. Epub 2007 Sep 14.
Many patients with rosacea are unable to tolerate extended treatment periods with topical agents because of the unusually high skin sensitivity that often accompanies rosacea. Kinetin (N(6)-furfuryladenine) is a plant cytokinin that reportedly helps restore skin barrier function and may be useful to ameliorate the signs and symptoms of rosacea. The purpose of this open-label study was to determine the tolerance and efficacy of twice-daily application of kinetin 0.1% lotion for improving the signs and symptoms of mild to moderate facial rosacea. Subjects applied kinetin 0.1% lotion twice daily to the face, with daily use of a sunscreen of sun protection factor 30. Subjects were evaluated at baseline and at 4-week intervals for 12 weeks to assess efficacy and tolerance. Results of this study suggest that kinetin 0.1% lotion is a well-tolerated moisturizing lotion option for subjects with mild to moderate inflammatory rosacea.
许多酒渣鼻患者由于酒渣鼻常伴有的异常高皮肤敏感性，无法耐受外用药物的长期治疗。激动素（N⁶-糠基腺嘌呤）是一种植物细胞分裂素，据报道有助于恢复皮肤屏障功能，可能有助于改善酒渣鼻的体征和症状。这项开放标签研究的目的是确定每日两次外用0.1%激动素洗剂改善轻至中度面部酒渣鼻体征和症状的耐受性和疗效。受试者每天两次将0.1%激动素洗剂涂抹于面部，并每天使用防晒系数为30的防晒霜。在基线时以及在12周内每隔4周对受试者进行评估，以评估疗效和耐受性。这项研究的结果表明，0.1%激动素洗剂对于轻至中度炎症性酒渣鼻患者是一种耐受性良好的保湿洗剂选择。
