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驻留型和激活型小鼠及大鼠腹膜巨噬细胞产生的精氨酸酶活性差异。

Differences in the arginase activity produced by resident and stimulated murine and rat peritoneal macrophages.

作者信息

Hrabák A, Antoni F, Csuka I

机构信息

1st Department of Biochemistry, Semmelweis University Medical School, Budapest, Hungary.

出版信息

Int J Biochem. 1991;23(10):997-1003. doi: 10.1016/0020-711x(91)90136-b.

DOI:10.1016/0020-711x(91)90136-b
PMID:1786860
Abstract
  1. Murine macrophages showed a considerably higher in vitro arginase production in short time cultures than rat peritoneal cells. 2. The in vivo stimulation with casein or thioglycollate resulted in an enhanced in vitro enzyme production in mice. 3. The adherence is not the condition of the enzyme production. 4. The difference between the two species cannot be explained by the lack of bivalent ions, the absence of energy supply, proteolysis, the low number of macrophages or by the different cell types of the peritoneal exudate of mouse and rat. 5. The lysozyme production of murine and rat peritoneal macrophages was also investigated and no difference was observed between the two species.
摘要
  1. 与大鼠腹膜细胞相比,小鼠巨噬细胞在短时间培养中体外精氨酸酶产量显著更高。2. 用酪蛋白或巯基乙酸盐进行体内刺激可提高小鼠体外酶产量。3. 黏附并非酶产生的条件。4. 这两个物种之间的差异不能用二价离子缺乏、能量供应缺失、蛋白水解、巨噬细胞数量少或小鼠和大鼠腹膜渗出液的不同细胞类型来解释。5. 还研究了小鼠和大鼠腹膜巨噬细胞的溶菌酶产生情况,未观察到两个物种之间存在差异。

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1
Differences in the arginase activity produced by resident and stimulated murine and rat peritoneal macrophages.驻留型和激活型小鼠及大鼠腹膜巨噬细胞产生的精氨酸酶活性差异。
Int J Biochem. 1991;23(10):997-1003. doi: 10.1016/0020-711x(91)90136-b.
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Stimulation of peritoneal cell arginase by bacterial lipopolysaccharides.细菌脂多糖对腹膜细胞精氨酸酶的刺激作用。
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Lack of response of murine peritoneal macrophages to in vitro activation by muramyl dipeptide (MDP). I. Macrophage activation by MDP is species dependent.鼠腹膜巨噬细胞对胞壁酰二肽(MDP)体外激活无反应。I. MDP对巨噬细胞的激活具有种属依赖性。
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Evidence for the pre-synthesized state of secreted macrophage arginase: arginase activity cannot be modified in short-term cultures.分泌型巨噬细胞精氨酸酶预合成状态的证据:精氨酸酶活性在短期培养中无法被改变。
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Parasitology. 1991 Aug;103 Pt 1:61-4. doi: 10.1017/s0031182000059291.

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L-Arginine availability modulates local nitric oxide production and parasite killing in experimental trypanosomiasis.L-精氨酸的可利用性调节实验性锥虫病中局部一氧化氮的产生和寄生虫杀伤。
Infect Immun. 2000 Aug;68(8):4653-7. doi: 10.1128/IAI.68.8.4653-4657.2000.
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Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines.巨噬细胞中胍丁胺的代谢:脂多糖和抑制性细胞因子的调节作用
Biochem J. 1998 Mar 15;330 ( Pt 3)(Pt 3):1405-9. doi: 10.1042/bj3301405.