Ogbogu Princess U, Rosing Douglas R, Horne McDonald K
Allergy and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room B1-05, Bldg. 4, Bethesda, MD 20892, USA.
Immunol Allergy Clin North Am. 2007 Aug;27(3):457-75. doi: 10.1016/j.iac.2007.07.001.
The hypereosinophilic syndromes (HESs) are characterized by persistent marked eosinophilia (>1500 eosinophils/mm(3)), the absence of a primary cause of eosinophilia (such as parasitic or allergic disease), and evidence of eosinophil-mediated end organ damage. Cardiovascular complications of HES are a major source of morbidity and mortality in these disorders. The most characteristic cardiovascular abnormality in HES is endomyocardial fibrosis. Patients who have an HES also may develop thrombosis, particularly in the cardiac ventricles, but also occasionally in deep veins. Because of the rarity of these disorders, specific guidelines for the management of the cardiac and thrombotic complications of HES are lacking. This article reviews the diagnosis and management of the cardiovascular manifestations of HES.
高嗜酸性粒细胞综合征（HESs）的特征为持续性显著嗜酸性粒细胞增多（>1500个嗜酸性粒细胞/mm³），不存在嗜酸性粒细胞增多的原发性病因（如寄生虫或过敏性疾病），并有嗜酸性粒细胞介导的终末器官损伤的证据。HES的心血管并发症是这些疾病发病和死亡的主要原因。HES最具特征性的心血管异常是心内膜纤维化。患有HES的患者也可能发生血栓形成，尤其是在心室，但偶尔也会在深静脉形成。由于这些疾病罕见，缺乏针对HES心脏和血栓并发症管理的具体指南。本文综述了HES心血管表现的诊断和管理。
