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海洋两亲性铁载体:海洋菌素的结构、摄取及微生物分配

Marine amphiphilic siderophores: marinobactin structure, uptake, and microbial partitioning.

作者信息

Martinez Jennifer S, Butler Alison

机构信息

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.

出版信息

J Inorg Biochem. 2007 Nov;101(11-12):1692-8. doi: 10.1016/j.jinorgbio.2007.07.007. Epub 2007 Jul 16.

Abstract

Marinobactins A-E are a suite of amphiphilic siderophores which have a common peptidic head group that coordinates Fe(III), and a fatty acid which varies in length and saturation. As a result of the amphiphilic properties of these siderophores it is difficult to study siderophore-mediated uptake of iron, because the amphiphilic siderophores partition indiscriminately in microbial and other membranes. An alternative method to distinguish amphiphilic siderophore partitioning versus siderophore-mediated active uptake for Fe(III)-marinobactin E has been developed. In addition, a new member of the marinobactin family of siderophores is also reported, marinobactin F, which has a C(18) fatty acid with one double bond and which is substantially more hydrophobic that marinobactins A-E.

摘要

海杆菌素A - E是一组两亲性铁载体,它们具有一个共同的用于配位Fe(III)的肽头部基团,以及一个长度和饱和度不同的脂肪酸。由于这些铁载体具有两亲性,因此很难研究铁载体介导的铁摄取,因为两亲性铁载体在微生物膜和其他膜中会无差别地分配。现已开发出一种区分两亲性铁载体分配与铁载体介导的Fe(III)-海杆菌素E主动摄取的替代方法。此外,还报道了铁载体海杆菌素家族的一个新成员,即海杆菌素F,它具有一个带有一个双键的C(18)脂肪酸,并且比海杆菌素A - E疏水性强得多。

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