Liang Mei, Zhang Ping, Fu Jian
Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA.
Cancer Lett. 2007 Dec 8;258(1):31-7. doi: 10.1016/j.canlet.2007.08.003. Epub 2007 Sep 14.
Adhesion of cancer cell to endothelial cells and the subsequent trans-endothelial migration are key steps in metastasis. However, the identities of the molecules mediating cancer cell/endothelial cell interaction are still not fully understood. In this study, we tested the hypothesis that lectin-like oxidized-low-density lipoprotein (oxLDL) receptor-1 (LOX-1), a key mediator of vascular inflammation and atherosclerosis expressed on endothelial cell surface, mediates breast cancer cell/endothelial cell interactions. We showed that up-regulation of endothelial LOX-1 by TNF-alpha promoted the adhesion and trans-endothelial migration of MDA-MB-231 breast cancer cells. Thus, endothelial LOX-1 could present a novel pathway in breast cancer metastasis.
癌细胞与内皮细胞的黏附以及随后的跨内皮迁移是转移过程中的关键步骤。然而，介导癌细胞/内皮细胞相互作用的分子身份仍未完全明确。在本研究中，我们检验了以下假设：凝集素样氧化型低密度脂蛋白（oxLDL）受体-1（LOX-1），一种在内皮细胞表面表达的血管炎症和动脉粥样硬化的关键介质，介导乳腺癌细胞/内皮细胞的相互作用。我们发现，肿瘤坏死因子-α（TNF-α）上调内皮细胞LOX-1可促进MDA-MB-231乳腺癌细胞的黏附和跨内皮迁移。因此，内皮细胞LOX-1可能是乳腺癌转移的一条新途径。
