慢性应激和氧化应激作为抑郁症和阿尔茨海默病发病机制的共同因素：抗氧化剂在预防和治疗中的作用
Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer's Disease: The Role of Antioxidants in Prevention and Treatment.
作者信息
Juszczyk Gabriela, Mikulska Joanna, Kasperek Kamila, Pietrzak Diana, Mrozek Weronika, Herbet Mariola
机构信息
Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8bStreet, 20-090 Lublin, Poland.
出版信息
Antioxidants (Basel). 2021 Sep 9;10(9):1439. doi: 10.3390/antiox10091439.
Abstract
There is a growing body of scientific research showing the link between depression and dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of oxidative stress in the parts of the brain involved in the development of depression and AD. The scientific literature reports the significant role of antioxidants, which are highly effective in treating these diseases. In this review, we have summarized the relationship between chronic stress, oxidative stress, and the changes in the brain they cause occurring in the brain. Among all the compounds showing antioxidant properties, the most promising results in AD treatment were observed for Vitamin E, coenzyme Q10 (CoQ10), melatonin, polyphenols, curcumin, and selenium. In case of depression treatment, the greatest potential was observed in curcumin, zinc, selenium, vitamin E, and saffron.
摘要
越来越多的科学研究表明，抑郁症与阿尔茨海默病（AD）中的痴呆症之间存在联系。慢性应激会导致大脑中与抑郁症和AD发展相关部位的氧化应激形成。科学文献报道了抗氧化剂的重要作用，其在治疗这些疾病方面非常有效。在这篇综述中，我们总结了慢性应激、氧化应激以及它们在大脑中引起的大脑变化之间的关系。在所有具有抗氧化特性的化合物中，维生素E、辅酶Q10（CoQ10）、褪黑素、多酚、姜黄素和硒在AD治疗中观察到了最有前景的结果。在抑郁症治疗方面，姜黄素、锌、硒、维生素E和藏红花表现出了最大的潜力。
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