Goodlad J R, Fletcher C D
Department of Histopathology, St Thomas's Hospital (UMDS), London, UK.
Histopathology. 1991 Dec;19(6):515-22. doi: 10.1111/j.1365-2559.1991.tb01499.x.
Solitary fibrous tumours ('pleural fibromas') are well-recognized in the pleura, but their rare occurrence at other sites has only become appreciated in recent years, as a consequence of which extrapleural examples often go unrecognized or misdiagnosed. Eight cases (three peritoneal, two retroperitoneal, two intrapulmonary and one mediastinal) are presented herein. All but one presented in adulthood, and three were asymptomatic chance findings. Size ranged from 0.8 to 26 cm in maximum diameter. To date, none has behaved in an aggressive fashion. Histologically, these lesions are entirely comparable to their pleural counterparts, and accurate diagnosis is largely dependent on appreciation of their potential extrapleural location. Immunohistochemistry in seven cases favoured myofibroblastic/fibroblastic differentiation, in keeping with the putative submesothelial origin of these lesions.
孤立性纤维性肿瘤（“胸膜纤维瘤”）在胸膜中已广为人知，但近年来人们才认识到它们在其他部位的罕见发生，因此胸膜外的病例常常未被识别或误诊。本文报告8例（3例发生于腹膜，2例发生于腹膜后，2例发生于肺内，1例发生于纵隔）。除1例以外，其余均在成年期发病，3例为无症状偶然发现。最大直径范围为0.8至26厘米。迄今为止，尚无病例表现出侵袭性。组织学上，这些病变与胸膜同类病变完全相似，准确诊断很大程度上取决于对其可能的胸膜外位置的认识。7例的免疫组化结果支持肌成纤维细胞/成纤维细胞分化，这与这些病变假定的间皮下起源一致。
