Caruso R A, LaSpada F, Gaeta M, Minutoli I, Inferrera C
Department of Human Pathology, University of Messina, Italy.
Diagn Cytopathol. 1996 Feb;14(1):64-7. doi: 10.1002/(SICI)1097-0339(199602)14:1<64::AID-DC13>3.0.CO;2-B.
The authors describe a rare case of intrapulmonary solitary fibrous tumor (SFT). Morphologically, the tumor showed a disorganized or "patternless" arrangement of plump to spindle cells in a collagenous stroma. Tumor cells were immunoreactive for vimentin, but not for keratin, carcinoembryonic antigen, epithelial membrane antigen, factor-VIII related antigen, S-100 protein, desmin, and actin. These immunohistochemical findings suggested fibroblastic differentiation, in keeping with the putative submesothelial origin of the tumor. The problems concerning the fine-needle aspiration (FNA) preoperative diagnosis of SFT are briefly discussed.
作者描述了一例罕见的肺内孤立性纤维性肿瘤（SFT）。形态学上，肿瘤在胶原性基质中表现为丰满至梭形细胞的无序或“无模式”排列。肿瘤细胞波形蛋白免疫反应阳性，但细胞角蛋白、癌胚抗原、上皮膜抗原、因子VIII相关抗原、S-100蛋白、结蛋白和肌动蛋白免疫反应阴性。这些免疫组化结果提示成纤维细胞分化，与肿瘤假定的间皮下起源一致。文中简要讨论了关于SFT细针穿刺抽吸（FNA）术前诊断的问题。
