Ramani P, Birch B R, Harland S J, Parkinson M C
Department of Histopathology, University College, London, UK.
Histopathology. 1991 Dec;19(6):551-4. doi: 10.1111/j.1365-2559.1991.tb01504.x.
In a study of 40 patients with high-grade (G2 and G3) transitional cell carcinoma of bladder invading the lamina propria--stage pT1, retraction artifact was often misdiagnosed as vascular/lymphatic tumour invasion. Vascular/lymphatic infiltration was diagnosed in five cases based on haematoxylin and eosin stained sections, but confirmed in only two of these using immunohistochemical techniques to demonstrate endothelial markers. Of the latter, these preparations demonstrating von-Willebrand factor and binding the monoclonal antibody QBEND/10 were technically superior to those in which Ulex europaeus agglutinin 1 was used. It is unlikely that the demonstration of vascular/lymphatic infiltration, a rare feature, will prove of value in defining prognostic groups for treatment.
在一项针对40例侵犯固有层（pT1期）的高级别（G2和G3）膀胱移行细胞癌患者的研究中，退缩假象常被误诊为血管/淋巴管肿瘤浸润。基于苏木精和伊红染色切片，5例被诊断为血管/淋巴管浸润，但使用免疫组化技术显示内皮标记物后，其中仅2例得到证实。在后者中，显示血管性血友病因子并结合单克隆抗体QBEND/10的标本在技术上优于使用欧洲荆豆凝集素1的标本。血管/淋巴管浸润这一罕见特征的显示，在确定治疗的预后分组方面不太可能具有价值。
