David Jean-Pierre
Group Bone Cell Differentiation, Deutsches Rheuma-Forschungszentrum (DRFZ), Cahritéplatz 1, Berlin, Germany.
Adv Immunol. 2007;95:149-65. doi: 10.1016/S0065-2776(07)95005-1.
Osteoimmunology can be defined in a very broad sense as the field of research focusing on interrelations between bone and the immune system. This is a rather opened field that covers at least three different issues. The first one is developmental, that is, organogenesis of the bones and immune systems. The second is post-developmental, that is, the role of the bone in the regulation of the immune response and role of the immune cells on the regulation of bone homeostasis. The third one is related to pathologies: Can immune cells be involved in the development of bone-related pathology? Can deregulation of the bone be causing immune-related diseases? I will not review in detail the bibliography covering osteoimmunology. This has been extensively done in Immunological Reviews (Vol. 208, December 2005) and Current Opinion in Rheumatology (Vol. 18, 2006). I will rather critically comment on hypotheses and concepts in osteoimmunology from a bone biologist's point of view.
骨免疫学在非常广泛的意义上可被定义为专注于骨骼与免疫系统之间相互关系的研究领域。这是一个相当开放的领域，至少涵盖三个不同的问题。第一个是发育方面的，即骨骼和免疫系统的器官发生。第二个是发育后方面的，即骨骼在免疫反应调节中的作用以及免疫细胞在骨稳态调节中的作用。第三个与病理学相关：免疫细胞会参与骨相关病理学的发展吗？骨骼失调会引发免疫相关疾病吗？我不会详细回顾涵盖骨免疫学的文献。这在《免疫学评论》（2005年12月第208卷）和《风湿病学当前观点》（2006年第18卷）中已有广泛论述。我将从骨生物学家的角度对骨免疫学中的假设和概念进行批判性评论。
